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Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants

Klinker, J. F. and Schwaner, I. and Offermanns, S. and Hagelüken, A. and Seifert, Roland (1994) Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants. Biochemical pharmacology 48 (10), pp. 1857-1864.

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Abstract

Dibutyryl cAMP-differentiated HL-60 human leukemia cells possess receptors for the chemoattractants N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), C5a and leukotriene B4 (LTB4). We compared the effects of these chemoattractants in HL-60 membranes and in intact HL-60 cells. fMLP, C5a and LTB4 stimulated GTP hydrolysis and guanosine 5'-O-[3-thio]triphosphate (GTP[gamma S]) binding in HL-60 ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
7986196PubMed ID
Classification:
NotationType
Bucladesine/pharmacologyMESH
Calcium/metabolismMESH
Cell Differentiation/drug effectsMESH
Complement C5a/pharmacologyMESH
Enzyme ActivationMESH
GTP Phosphohydrolases/metabolismMESH
Guanosine 5'-O-(3-Thiotriphosphate)/metabolismMESH
Guanosine Triphosphate/metabolismMESH
HumansMESH
HydrolysisMESH
Leukemia/pathologyMESH
Leukotriene B4/pharmacologyMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Signal TransductionMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:27
Last Modified:13 Mar 2014 18:30
Item ID:23305
Owner Only: item control page
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