Startseite UB

Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis

Blunk, Torsten and Hochstrasser, D. F. and Sanchez, J. C. and Müller, B. W. and Müller, R. H. (1993) Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis. Electrophoresis 14 (12), pp. 1382-1387.

[img]
Preview
PDF
Download (649kB)

at PubMed


Abstract

Targeting to specific sites of the body via colloidal carriers is sought in order to reduce drug side effects. The adsorption of plasma proteins on intravenously injected particles is regarded as the key factor in explaining their organ distribution: total bound protein, or, more likely, the presence of specific proteins and their conformation, are expected to influence macrophage uptake. ...

plus


Export bibliographical data



Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
8137807PubMed ID
Classification:
NotationType
AdsorptionMESH
Apolipoproteins/analysisMESH
Blood Proteins/metabolismMESH
Chemistry, PhysicalMESH
ColloidsMESH
Complement Factor B/analysisMESH
Drug CarriersMESH
Electrophoresis, Gel, Two-DimensionalMESH
Fibrinogen/analysisMESH
HumansMESH
Injections, IntravenousMESH
MicrospheresMESH
Physicochemical PhenomenaMESH
Polystyrenes/chemistryMESH
Transferrin/analysisMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:27 Jan 2012 07:22
Last Modified:13 Mar 2014 18:31
Item ID:23312
Owner Only: item control page

Downloads

Downloads per month over past year

  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact