Hanslmayr, Simon and Backes, Heidelore and Straub, Sarah and Popov, Tzvetan and Langguth, Berthold and Hajak, Göran and Bäuml, Karl-Heinz T. and Landgrebe, Michael (2013) Enhanced resting-state oscillations in schizophrenia are associated with decreased synchronization during inattentional blindness. Human Brain Mapping 34 (9), pp. 2266-2275.
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Patients suffering from schizophrenia have been characterized by an apparent lack of theta (around 6 Hz) and gamma (>40Hz) brain oscillatory activity during task execution. The neurocognitive reasons for these abnormal synchronization patterns, however, remain elusive. Recording the EEG during a selective visual attention task, the current study investigates whether abnormal brain oscillatory resting-state activity in the theta band might account for a lack of task-related brain oscillatory activity in schizophrenia. EEGs were recorded from 26 patients with schizophrenia and 26 healthy matched controls during rest and during the execution of a selective visual attention task, in which an unexpected object (monkey) appeared on the screen. On a behavioral level, patients were less likely to report perceiving the unexpected event than controls. Controls showed a stronger increase in task-related theta power than patients in prefrontal, parietal and occipital brain regions. Task-related theta power change differed between patients who perceived, and patients who did not perceive the unexpected event. Moreover, patients showed higher levels of theta power during rest than controls while the absolute theta power values during the selective attention task did not differ between groups. These results suggest that the failure to increase oscillatory activity during a cognitive task can be accounted for by abnormally high oscillatory activity in a resting state. This finding has important implications for future studies examining abnormal brain oscillatory activity in schizophrenia, which usually treat resting-state activity as a baseline for task-related activity.
|Institutions:||Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie IV (Entwicklungs- und Kognitionspsychologie) - Prof. Dr. Karl-Heinz Bäuml|
|Keywords:||Synchronization, Schizophrenia, Theta, Oscillations, Resting State, Inattentional Blindness|
|Subjects:||100 Philosophy & psychology > 150 Psychology|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Deposited On:||03 Feb 2012 07:29|
|Last Modified:||22 Aug 2013 08:09|