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Nonspecific Cation Current Associated with Native Polycystin-2 in HEK-293 Cells

Pelucchi, Bruna and Aguiari, Gianluca and Pignatelli, Angela and Manzati, Elisa and Witzgall, Ralph and Senno, Laura del and Belluzzi, Ottorino (2006) Nonspecific Cation Current Associated with Native Polycystin-2 in HEK-293 Cells. Journal of the American Society of Nephrology - JASN 17 (2), pp. 388-397.

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Other URL: http://jasn.asnjournals.org/cgi/content/abstract/17/2/388


Mutations in either PKD1 or PKD2 gene are associated with autosomal dominant polycystic kidney disease, the most common inherited kidney disorder. Polycystin-2 (PC2), the PKD2 gene product, and the related protein polycystin-L, function as Ca2+-permeable, nonselective cation channels in different expression systems. This work describes a nonspecific cation current (ICC) that is present in native ...


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Item Type:Article
Institutions:Biology, Preclinical Medicine > Institut für Anatomie
Identification Number:
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Deposited On:02 Aug 2006
Last Modified:25 Jul 2011 08:20
Item ID:234
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