Mao, Changhui and Brown, Christopher R. and Griesenbeck, Joachim and Boeger, Hinrich
Occlusion of regulatory sequences by promoter nucleosomes in vivo.
PloS one 6 (3), e17521.
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Nucleosomes are believed to inhibit DNA binding by transcription factors. Theoretical attempts to understand the significance of nucleosomes in gene expression and regulation are based upon this assumption. However, nucleosomal inhibition of transcription factor binding to DNA is not complete. Rather, access to nucleosomal DNA depends on a number of factors, including the stereochemistry of ...
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