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Vesicles and Micelles from Amphiphilic Zinc(II)−Cyclen Complexes as Highly Potent Promoters of Hydrolytic DNA Cleavage

Gruber, Benjamin and Kataev, Evgeny and Aschenbrenner, Jana and Stadlbauer, Stefan and König, Burkhard (2011) Vesicles and Micelles from Amphiphilic Zinc(II)−Cyclen Complexes as Highly Potent Promoters of Hydrolytic DNA Cleavage. Journal of the American Chemical Society 133 (51), pp. 20704-20707.

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Abstract

Phosphate esters are essential to any living organism and their specific hydrolysis plays an important role in many metabolic processes. As phosphodiester bonds can be extraordinary stable, as in DNA, great effort has been put into mimicking the active sites of hydrolytic enzymes which can easily cleave these linkages and were often found to contain one or more coordinated metal ions. With this ...

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Item Type:Article
Date:2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:DFG
Identification Number:
ValueType
10.1021/ja209247wDOI
22121825PubMed ID
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:23 Mar 2012 07:33
Last Modified:23 Mar 2012 07:33
Item ID:23619

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