Schecklmann, Martin and Volberg, Gregor and Frank, Gabriele and Hadersdorfer, Julia and Steffens, Thomas and Weisz, Nathan and Landgrebe, Michael and Hajak, Göran and Greenlee, Mark W. and Classen, Joseph and Langguth, Berthold (2011) Paired associative stimulation of the auditory system: a proof-of-principle study. PloS one 6 (11), e27088.
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Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to investigate whether the auditory system can be modulated by PAS.
Acoustic stimuli (4 kHz) were paired with TMS of the auditory cortex with intervals of either 45 ms (PAS(45 ms)) or 10 ms (PAS(10 ms)). Two-hundred paired stimuli were applied at 0.1 Hz and effects were compared with low frequency repetitive TMS (rTMS) at 0.1 Hz (200 stimuli) and 1 Hz (1000 stimuli) in eleven healthy students. Auditory cortex excitability was measured before and after the interventions by long latency auditory evoked potentials (AEPs) for the tone (4 kHz) used in the pairing, and a control tone (1 kHz) in a within subjects design.
Amplitudes of the N1-P2 complex were reduced for the 4 kHz tone after both PAS(45 ms) and PAS(10 ms), but not after the 0.1 Hz and 1 Hz rTMS protocols with more pronounced effects for PAS(45 ms). Similar, but less pronounced effects were observed for the 1 kHz control tone.
These findings indicate that paired associative stimulation may induce tonotopically specific and also tone unspecific human auditory cortex plasticity.
|Institutions:|| Medicine > Lehrstuhl für Psychiatrie und Psychotherapie|
Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee
|Projects:||Open Access Publizieren (DFG)|
|Subjects:||100 Philosophy & psychology > 150 Psychology|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Deposited On:||11 Apr 2012 11:08|
|Last Modified:||25 Mar 2013 15:01|
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