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Interaction of bestrophin-1 and Ca2+ channel β-subunits: identification of new binding domains on the bestrophin-1 C-terminus.

Milenkovic, Vladimir M. and Krejcova, Sarka and Reichhart, Nadine and Wagner, Andrea and Strauss, Olaf (2011) Interaction of bestrophin-1 and Ca2+ channel β-subunits: identification of new binding domains on the bestrophin-1 C-terminus. PloS one 6 (4), e19364.

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Abstract

Bestrophin-1 modulates currents through voltage-dependent L-type Ca(2+) channels by physically interacting with the β-subunits of Ca(2+) channels. The main function of β-subunits is to regulate the number of pore-forming Ca(V)-subunits in the cell membrane and modulate Ca(2+) channel currents. To understand the influence of full-length bestrophin-1 on β-subunit function, we studied binding and ...

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Item Type:Article
Date:29 April 2011
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Identification Number:
ValueType
15530640PubMed ID
10.1371/journal.pone.0019364DOI
Classification:
NotationType
Amino Acid MotifsMESH
AnimalsMESH
CHO CellsMESH
Calcium Channels/chemistryMESH
Chloride Channels/chemistryMESH
CricetinaeMESH
CricetulusMESH
Eye Proteins/chemistryMESH
HEK293 CellsMESH
HumansMESH
Microscopy, Confocal/methodsMESH
Patch-Clamp TechniquesMESH
Protein BindingMESH
Protein ConformationMESH
Protein Structure, SecondaryMESH
Protein Structure, TertiaryMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:11 Apr 2012 09:07
Last Modified:13 Mar 2014 18:45
Item ID:23751
Owner Only: item control page
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