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PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response.

Karrasch, Thomas and Spaeth, Tanja and Allard, Brigitte and Jobin, Christian (2011) PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response. PloS one 6 (10), e26340.

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Abstract

We conclude that PI3K-mediated GSK3ß phosphorylation is involved in the intestinal epithelial wound-healing response. Phosphorylation of GSK3ß may be important for intestinal restitution by promoting cell motility in response to wounding.

Item Type:

Article

Institutions:

Medicine > Lehrstuhl für Innere Medizin I

Identification Number:

Value	Type
22039465	PubMed ID
10.1371/journal.pone.0026340	DOI

Classification:

Notation	Type
Animals	MESH
Base Sequence	MESH
Blotting, Western	MESH
Cell Line	MESH
DNA Primers	MESH
Glycogen Synthase Kinase 3/metabolism	MESH
Intestinal Mucosa/pathology	MESH
Mice	MESH
Mice, Knockout	MESH
Phosphatidylinositol 3-Kinases/metabolism	MESH
Phosphorylation	MESH
Protein Transport	MESH
Rats	MESH
Real-Time Polymerase Chain Reaction	MESH
Serine/metabolism	MESH
Signal Transduction	MESH
Wound Healing	MESH
beta Catenin/metabolism	MESH