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Synthesis and application of the first radioligand targeting the allosteric binding pocket of chemokine receptor CXCR3

Bernat, Viachaslau and Heinrich, Markus and Baumeister, Paul and Buschauer, Armin and Tschammer, Nuska (2012) Synthesis and application of the first radioligand targeting the allosteric binding pocket of chemokine receptor CXCR3. ChemMedChem 7 (8), pp. 1481-1489.

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Abstract

Strategies for the identification of allosteric modulators of chemokine receptors largely rely on various cell-based functional assays. Radioligand binding assays are typically not available for allosteric binding sites. We synthesized, purified, and applied the first tritium-labeled allosteric modulator of thehuman chemokine receptor CXCR3 (RAMX3, ...

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Item Type:Article
Date:2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1002/cmdc.201200184DOI
22689503PubMed ID
Related URLs:
URLURL Type
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201200184/abstract;jsessionid=2B854734EB5302FCE27A5D98B19D795E.d01t02Publisher
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201200184/suppinfoSupplementary Material
Keywords:allosteric modulation; chemokine receptors; CXCR3; GPCRs; radioligands
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:04 Jun 2012 13:20
Last Modified:31 Jul 2012 18:55
Item ID:24694
Owner Only: item control page
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