Müller, Rainer and Heckmann, Klaus and Angele, Peter and Kujat, R. and Nerlich, Michael (2007) Improving the biocompatibility of titanium- and cobalt-based biomaterials by covalent immobilization of crosslinked collagen. In: Breme, Jürgen, (ed.) Metallic Biomaterial Interfaces. Wiley-VCH, Weinheim, pp. 88-92. ISBN 978-3-527-31860-5.
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The surfaces of titanium- and cobalt-based biomaterials with layers of fibrillar type-I collagen were coated to enhance initial osteoblast adhesion and implant-tissue integration. The coating procedure for biofunctionalization of metallic implant materials was presented. Surface d. of amino groups was elevated which resulted to a higher d. of covalent linkages which improved the stability of the surface-bound collagen layer. The pos. effect on cell behavior did not depend on the type of metal to which the collagen was immobilized.
|Item Type:||Book Section|
|Institutions:||Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz|
|Keywords:||titanium cobalt biomaterial biocompatibility covalent immobilization crosslinked collagen|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||19 Jun 2012 06:33|
|Last Modified:||19 Jun 2012 06:33|