Improving the biocompatibility of titanium- and cobalt-based biomaterials by covalent immobilization of crosslinked collagen

Abstract

The surfaces of titanium- and cobalt-based biomaterials with layers of fibrillar type-I collagen were coated to enhance initial osteoblast adhesion and implant-tissue integration. The coating procedure for biofunctionalization of metallic implant materials was presented. Surface d. of amino groups was elevated which resulted to a higher d. of covalent linkages which improved the stability of the surface-bound collagen layer. The pos. effect on cell behavior did not depend on the type of metal to which the collagen was immobilized.