Dietrich, Susanne and Borst, Nadine and Schlee, Sandra and Schneider, Daniel and Janda, Jan-Oliver and Sterner, Reinhard and Merkl, Rainer (2012) Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments. Biochemistry.
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The analysis of a multiple sequence alignment (MSA) with correlation methods identifies for a protein pairs of residue-positions whose occupation with amino acids change in a concerted manner. It is plausible to assume that positions that are a member of many such correlation pairs are important for protein function or stability. We have used the algorithm H2r to identify positions k in the MSAs ...
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|Date:||27 June 2012|
|Institutions:||Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner > Arbeitsgruppe PD Dr. Rainer Merkl|
|Subjects:||500 Science > 570 Life sciences|
000 Computer science, information & general works > 004 Computer science
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||09 Jul 2012 14:11|
|Last Modified:||09 Jul 2012 14:14|