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Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments

Dietrich, Susanne and Borst, Nadine and Schlee, Sandra and Schneider, Daniel and Janda, Jan-Oliver and Sterner, Reinhard and Merkl, Rainer (2012) Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments. Biochemistry.

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Abstract

The analysis of a multiple sequence alignment (MSA) with correlation methods identifies for a protein pairs of residue-positions whose occupation with amino acids change in a concerted manner. It is plausible to assume that positions that are a member of many such correlation pairs are important for protein function or stability. We have used the algorithm H2r to identify positions k in the MSAs ...

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Item Type:Article
Date:27 June 2012
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner > Arbeitsgruppe PD Dr. Rainer Merkl
Identification Number:
ValueType
22737967PubMed ID
10.1021/bi300747rDOI
Subjects:500 Science > 570 Life sciences
000 Computer science, information & general works > 004 Computer science
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Rainer Merkl
Deposited On:09 Jul 2012 14:11
Last Modified:09 Jul 2012 14:14
Item ID:25302
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