Startseite UB

Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-dopa in models of Parkinson's disease

Löschmann, P. A. and Lange, Klaus W. and Kunow, M. and Rettig, K. J. and Jähnig, P. and Honoré, T. and Turski, L. and Wachtel, H. and Jenner, P. and Marsden, C. D. (1991) Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-dopa in models of Parkinson's disease. Journal of neural transmission. Parkinson's disease and dementia section 3 (3), pp. 203-213.

[img]
Preview
PDF
Download (829kB)

at PubMed


Abstract

Degeneration of dopaminergic nigrostriatal neurons in Parkinson's disease results in an overactivity of excitatory glutamatergic projections from the subthalamic nucleus to the output nuclei of the basal ganglia resulting in rigidity and akinesia. In theory pharmacological blockade of these overactive systems should improve parkinsonian symptomatology. The selective AMPA-antagonist NBQX and the ...

plus


Export bibliographical data

Item Type:Article
Date:1991
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
1835581PubMed ID
Classification:
NotationType
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacologyMESH
Analysis of VarianceMESH
AnimalsMESH
CallithrixMESH
Disease Models, AnimalMESH
Drug SynergismMESH
Ibotenic Acid/antagonists & inhibitorsMESH
Levodopa/pharmacologyMESH
MaleMESH
Motor Activity/drug effectsMESH
Oxidopamine/pharmacologyMESH
Parkinson Disease, Secondary/etiologyMESH
Piperazines/pharmacologyMESH
Quinoxalines/pharmacologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, N-Methyl-D-Aspartate/antagonists & inhibitorsMESH
Substantia Nigra/drug effectsMESH
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidMESH
Subjects:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Jul 2012 09:49
Last Modified:13 Mar 2014 19:03
Item ID:25439
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact