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The antiparkinsonian actions and pharmacokinetics of transdermal (+)-4-propyl-9-hydroxynaphthoxazine (+PHNO): preliminary results

Coleman, R. J. and Lange, Klaus W. and Quinn, N. P. and Loper, A. E. and Bondi, J. V. and Hichens, M. and Stahl, S. M. and Marsden, C. D. (1989) The antiparkinsonian actions and pharmacokinetics of transdermal (+)-4-propyl-9-hydroxynaphthoxazine (+PHNO): preliminary results. Movement disorders 4 (2), pp. 129-138.

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Abstract

(+)-4-Propyl-9-hydroxynaphthoxazine (+PHNO) is a potent dopamine agonist that has been administered transdermally to four patients with Parkinson's disease and "on-off" fluctuations. Skin patches of increasing size were used to treat these patients, who also received infrequent doses of oral levodopa if required. The effect of +PHNO was measured as an increased duration of action of individual ...

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Item Type:Article
Date:1989
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
2733705PubMed ID
10.1002/mds.870040204DOI
Classification:
NotationType
Administration, CutaneousMESH
AdultMESH
Antiparkinson Agents/pharmacokineticsMESH
Dopamine AntagonistsMESH
Drug Administration ScheduleMESH
Drug Therapy, CombinationMESH
HumansMESH
Levodopa/administration & dosageMESH
Middle AgedMESH
Motor Skills/drug effectsMESH
Oxazines/pharmacokineticsMESH
Parkinson Disease/drug therapyMESH
Subjects:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Jul 2012 13:25
Last Modified:13 Mar 2014 19:03
Item ID:25449
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