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Analysis of the anti-fibrotic effects of hop bitter acids on hepatic stellate cells and their anti-tumorigenic effects on hepatocellular carcinoma cells

URN to cite this document: urn:nbn:de:bvb:355-epub-256071

Saugspier, Michael Sebastian (2012) Analysis of the anti-fibrotic effects of hop bitter acids on hepatic stellate cells and their anti-tumorigenic effects on hepatocellular carcinoma cells. PhD, Universität Regensburg

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Abstract (English)

Bitter acids (BA) from the hop plant Humulus lupulus L. exhibit multiple beneficial biological properties. However, no studies are available regarding the effects of hop bitter acids on liver cells or chronic liver diseases, respectively. Chronic liver diseases are accompanied by chronic hepatic inflammation which can lead to liver fibrosis. If left untreated, liver fibrosis can progress to ...

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Translation of the abstract (German)

Bittersäuren (BA) aus der Hopfenpflanze Humulus lupulus (L.) besitzen eine Reihe positiver biologischer Eigenschaften. Jedoch sind Wirkungen von BA auf Leberzellen bzw. chronischen Lebererkrankungen weitgehend unbekannt. Chronische Lebererkrankungen gehen einher mit chronischer, hepatischer Entzündung, welche zur Leberfibrose führen kann. Ohne Behandlung kann die Leberfibrose zur Leberzirrhose ...

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Export bibliographical data



Item Type:Thesis of the University of Regensburg (PhD)
Date:16 August 2012
Referee:Prof. Dr. Jörg Heilmann
Date of exam:6 August 2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Research groups and research centres:Not selected
Keywords:Hopfen, Humulus lupulus, Bittersäuren, humulone, lupulone, Leberfibrose, Hepatozelluläres Karzinom, hepatische Sternzelle, hop, bitter acids, liver, liver fibrosis, hepatocellular carcinoma, NF kappaB
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:16 Aug 2012 08:12
Last Modified:13 Mar 2014 19:06
Item ID:25607
Owner Only: item control page

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