Hanslmayr, Simon and Volberg, Gregor and Wimber, Maria and Oehler, Nora and Staudigl, Tobias and Hartmann, Thomas and Raabe, Markus and Greenlee, Mark W. and Bäuml, Karl-Heinz T. (2012) Prefrontally driven down-regulation of neural synchrony mediates goal-directed forgetting. The Journal of Neuroscience 32 (42), pp. 14742-14751.
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Neural synchronization between distant cell assemblies is crucial for the formation of new memories. To date, however, it remains unclear whether higher-order brain regions can adaptively regulate neural synchrony to control memory processing in humans. We explored this question in two experiments using a voluntary forgetting task. In the first experiment, we simultaneously recorded electroencephalography (EEG) along with functional magnetic resonance imaging (fMRI). The results show that a reduction in neural synchrony goes hand-in-hand with a BOLD signal increase in the left dorsolateral prefrontal cortex (dlPFC) when participants are cued to forget previously studied information. In the second experiment, we directly stimulated the left dlPFC with repetitive transcranial-magnetic-stimulation (rTMS) during the same task, and show that such stimulation specifically boosts the behavioral forgetting effect and induces a reduction in neural synchrony. These results suggest that prefrontally driven downregulation of long-range neural synchronization mediates goal-directed forgetting of longterm memories.
|Institutions:||Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie IV (Entwicklungs- und Kognitionspsychologie) - Prof. Dr. Karl-Heinz Bäuml|
|Subjects:||100 Philosophy & psychology > 150 Psychology|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||30 Aug 2012 08:55|
|Last Modified:||18 Oct 2012 08:45|