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Isoflurane Induces Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier in a Transdifferentiated Human Umbilical Vein Edothelial Cell Model

Dittmar, Michael S. and Petermichl, Walter and Schlachetzki, Felix and Graf, Bernhard M. and Gruber, Michael (2012) Isoflurane Induces Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier in a Transdifferentiated Human Umbilical Vein Edothelial Cell Model. Plos One 7, e38260.

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Abstract

Isoflurane is a popular volatile anesthetic agent used in humans as well as in experimental animal research. In previous animal studies of the blood-brain barrier (BBB), observations towards an increased permeability after exposure to isoflurane are reported. In this study we investigated the effect of a 2-hour isoflurane exposure on apoptosis of the cerebral endothelium following 24 hours of ...

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Item Type:Article
Date:18 June 2012
Institutions:Medicine > Lehrstuhl für Anästhesiologie
Medicine > Lehrstuhl für Neurologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0038260DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:07 Sep 2012 06:59
Last Modified:13 Mar 2014 19:11
Item ID:25834
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