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E3-14.7K Is Recruited to TNF-Receptor 1 and Blocks TNF Cytolysis Independent from Interaction with Optineurin

Klingeisen, Laura and Ehrenschwender, Martin and Heigl, Ulrike and Wajant, Harald and Hehlgans, Thomas and Schütze, Stefan and Schneider-Brachert, Wulf (2012) E3-14.7K Is Recruited to TNF-Receptor 1 and Blocks TNF Cytolysis Independent from Interaction with Optineurin. PloS One 7, e38348.

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Abstract

Escape from the host immune system is essential for intracellular pathogens. The adenoviral protein E3-14.7K (14.7K) is known as a general inhibitor of tumor necrosis factor (TNF)-induced apoptosis. It efficiently blocks TNF-receptor 1 (TNFR1) internalization but the underlying molecular mechanism still remains elusive. Direct interaction of 14.7K and/or associated proteins with the TNFR1 complex ...

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Item Type:Article
Date:4 June 2012
Institutions:Medicine > Lehrstuhl für Immunologie
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0038348DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:07 Sep 2012 07:02
Last Modified:13 Mar 2014 19:12
Item ID:25857
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