Stankova, Trayana and Eichhammer, Peter and Langguth, Berthold and Sand, Philipp G. (2012) Sexually dimorphic effects of oxytocin receptor gene (OXTR) variants on Harm Avoidance. Biology of Sex Differences 3, p. 17.
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Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles. Little is known, however, on a putative role of the gene in heritable temperamental traits.
We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory.
When sex was controlled for and an OXTR genotype*sex interaction term was included in the regression model, 11 % of the variance in Harm Avoidance could be explained (uncorrected p [less than or equal to] 0.01). Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant.
Findings lend support to a modulatory effect of common OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in anxiety phenotypes to identify more explanatory functional variation.
|Institutions:||Medicine > Lehrstuhl für Psychiatrie und Psychotherapie|
|Projects:||Open Access Publizieren (DFG)|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||07 Sep 2012 08:41|
|Last Modified:||20 Mar 2013 14:40|
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