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Mesenchymal stem cell grafts promote oligodendroglial differentiation after spinal cord injury

URN to cite this document: urn:nbn:de:bvb:355-epub-259949

Bründl, Johannes (2012) Mesenchymal stem cell grafts promote oligodendroglial differentiation after spinal cord injury. PhD, Universität Regensburg

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Abstract (English)

Transplantation of MSC into the acute injured spinal cord is sufficient to enhance oligodendroglial differentiation of endogenous spinal cord progenitor cells up to one month post-injury. Results from the present study and previously published data confirm that underyling mechanisms are based on (a) soluble factor(s) secreted by MSC, which create a specific microenvironment supporting ...

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Translation of the abstract (German)

Im Rahmen traumatischer Rückenmarkverletzungen kommt es regelmäßig zu schweren und permanenten neurologischen Funktionsstörungen bzw. -ausfällen. Der irreversible Verlust ortsständiger Rückenmarkzellen einschließlich Neuronen, Astrozyten und Oligodendrozyten sowie die damit einhergehenden ausgeprägten strukturellen Veränderungen repräsentieren das morphologische Korrelat für die schweren ...

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Export bibliographical data



Item Type:Thesis of the University of Regensburg (PhD)
Date:5 October 2012
Referee:Prof. Dr. Norbert Weidner and Prof. Dr. Peter Angele
Date of exam:2 October 2012
Institutions:Medicine > Lehrstuhl für Neurologie
Keywords:Mesenchymal, stem cell, transplantation, spinal cord injury, endogenous differentiation
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:05 Oct 2012 06:40
Last Modified:13 Mar 2014 19:16
Item ID:25994
Owner Only: item control page

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