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An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice

Barth, Thomas and Schmidt, Dominic and Botteron, Catherine and Nguyen, Trang T. T. and Ritter, Uwe and Männel, Daniela N. and Lechner, Anja (2012) An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice. Plos One 7, e44499.

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Abstract

Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection. The chemokine receptor CCR6 is shared by anti-inflammatory regulatory T cells and pro-inflammatory Th17 cells. In a recent study we showed that C57BL/6 mice deficient in CCR6 exhibited ...

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Item Type:Article
Date:28 September 2012
Institutions:Medicine > Lehrstuhl für Immunologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0044499DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:09 Oct 2012 11:56
Last Modified:13 Mar 2014 19:16
Item ID:26017
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