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Generation of myeloid-derived suppressor cells using prostaglandin E2

Obermajer, Natasa and Kalinski, Pawel (2012) Generation of myeloid-derived suppressor cells using prostaglandin E2. Transplantation Research 1, p. 15.

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Abstract

Myeloid-derived suppressor cells (MDSCs) are natural immunosuppressive cells and endogenous inhibitors of the immune system. We describe a simple and clinically-compatible method of generating large numbers of MDSCs, using the cultures of peripheral blood-isolated monocytes supplemented with prostaglandin E2 (PGE2). We observed that PGE2 induces endogenous COX2 expression in cultured monocytes, ...

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Item Type:Article
Date:28 September 2012
Institutions:Medicine > Lehrstuhl für Chirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/2047-1440-1-15DOI
Keywords:Cancer; COX2; Dendritic cells; Human; Immune dysfunction; Immunotherapy; Myeloid-derived suppressor cells; PGE2; Transplantation
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:23 Oct 2012 06:38
Last Modified:13 Mar 2014 19:57
Item ID:26081
Owner Only: item control page

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