Eggenhofer, Elke and Hoogduijn, Martin J. (2012) Mesenchymal stem cell-educated Macrophages. Transplantation Research 1, p. 12.
|License: Creative Commons Attribution|
PDF - Published Version
Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.
|Date:||28 September 2012|
|Institutions:||Medicine > Lehrstuhl für Chirurgie|
|Projects:||Open Access Publizieren (DFG)|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Partially|
|Deposited On:||23 Oct 2012 06:38|
|Last Modified:||19 Mar 2013 10:20|