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Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation

URN to cite this document: urn:nbn:de:bvb:355-epub-265318

Nießen, Christoph (2012) Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation. PhD, Universität Regensburg

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Abstract (English)

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to cirrhosis. Hepatocellular lipid accumulation is a hallmark of both nonalcoholic steatosis and steatohepatitis (NASH). The latter develops upon pro-inflammatory cell infiltration and is widely considered as the first relevant pathophysiological step in NAFLD-progression. The chemokine CCL5/RANTES plays ...

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Translation of the abstract (German)

Einführung Die nicht-alkoholische Fettlebererkrankung beschreibt ein weites Spektrum von Erkrankungen, das von einfacher Leberverfettung (Steatosis) bis zu nichtalkoholischer Steatohepatitis, die mit als Hauptursache der nicht-cholestatischen Leberzirrhose und damit als Vorstufe eines Leberzellkarzinomes gilt. Die genaue Ursache der nicht-alkoholischen Fettleberhepatitis ist nicht genau bekannt. ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:25 October 2012
Referee:Prof. Dr. Claus Hellerbrand and Prof. Dr. Andreas Schreyer
Date of exam:9 October 2012
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Keywords:NAFLD, RANTES, Steatosis hepatis
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Oct 2012 09:02
Last Modified:13 Mar 2014 19:19
Item ID:26531
Owner Only: item control page

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