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Novel azulene derivatives for the treatment of erectile dysfunction

Löber, Stefan and Hübner, Harald and Buschauer, Armin and Sanna, Fabrizio and Argiolas, Antonio and Melis, Maria Rosaria and Gmeiner, Peter (2012) Novel azulene derivatives for the treatment of erectile dysfunction. Bioorganic & medicinal chemistry letters 22 (23), pp. 7151-7154.

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Abstract

Based on the dopamine D(4) receptor partial agonist FAUC 3019, a series of azulenylmethylpiperazines was synthesized and affinities for the monoaminergic GPCRs including dopamine, serotonin, histamine and α-adrenergic receptor subtypes were determined. Ligand efficacies of the most promising test compounds revealed the N,N-dimethylaminomethyl substituted azulene 11 to be the most potent D(4) ...

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Item Type:Article
Date:6 October 2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
23099096PubMed ID
10.1016/j.bmcl.2012.09.064DOI
Related URLs:
URLURL Type
http://www.sciencedirect.com/science/article/pii/S0960894X1201219X#MMCvFirstSupplementary Material
Keywords:Penile erection; Erectile dysfunction; Azulene; Dopamine D4; Partial agonists
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:30 Oct 2012 14:06
Last Modified:31 Oct 2012 19:52
Item ID:26576
Owner Only: item control page
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