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The Neuropeptide Y Y1 receptor: a diagnostic marker? Expression in MCF-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts

Memminger, Martin and Keller, Max and Lopuch, Miroslaw and Pop, Nathalie and Bernhardt, Günther and von Angerer, Erwin and Buschauer, Armin (2012) The Neuropeptide Y Y1 receptor: a diagnostic marker? Expression in MCF-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts. PLoS ONE 7 (12), e51032.

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Memminger et al., PLoS ONE 7(12): e51032. doi:10.1371/journal.pone.0051032
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Abstract

The neuropeptide Y (NPY) Y1 receptor (Y1R) has been suggested as a tumor marker for in vivo imaging and as a therapeutic target. In view of the assumed link between estrogen receptor (ER) and Y1R in mammary carcinoma and with respect to the development of new diagnostic tools we investigated the Y1R protein expression in human MCF-7 cell variants differing in ER content and sensitivity against ...

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Item Type:Article
Date:7 December 2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie, Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0051032DOI
http://dx.plos.org/10.1371/journal.pone.0051032DOI
23236424PubMed ID
Keywords:neuropeptide Y; Y1 receptor; G-protein coupled receptor; estrogen receptor; imaging; MCF-7 breast cancer; xenograft; nude mice; autoradiography; radioligand; [3H]-UR-MK114; argininamides; antiestrogen; tamoxifen; diagnostic marker
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:30 Oct 2012 15:02
Last Modified:13 Mar 2014 19:35
Item ID:26578
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