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Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate

Rottlaender, Dennis and Matthes, Jan and Vatner, Stephen F. and Seifert, Roland and Herzig, Stefan (2007) Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate.
Journal of Pharmacology and Experimental Therapeutics 321 (2), pp. 608-615.

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Other URL: http://jpet.aspetjournals.org/cgi/content/abstract/321/2/608


Abstract

β₁-Adrenergic receptor activation stimulates cardiac L-type Ca²⁺ channels via adenylyl cyclases (ACs), with AC5 and AC6 being the most important cardiac isoforms. Recently, we have identified 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[γ-thio-]triphosphate (MANT-GTPγS) as a potent competitive AC inhibitor. Intriguingly, MANT-GTPγS inhibits AC5 and -6 more potently than other cyclases. These ...

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Export bibliographical data

Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
10.1124/jpet.106.118422DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:28 Jan 2008 15:10
Last Modified:13 Mar 2014 10:20
Item ID:2668
Owner Only: item control page
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