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Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics.

Appl, Heidrun and Holzammer, Tobias and Dove, Stefan and Haen, Ekkehard and Strasser, Andrea and Seifert, Roland (2012) Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics. Naunyn-Schmiedeberg's archives of pharmacology 385 (2), pp. 145-170.

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Abstract

Antidepressants and antipsychotics affect multiple molecular targets. Consequently, these drugs exhibit not only unique profiles of therapeutic effects but also several undesired effects. Histamine receptors (H₁R, H₂R, H₃R, and H₄R) belong to the large family of G protein-coupled receptors and are very important drug targets. All four H(x)R subtypes are expressed in the CNS. Interactions of ...

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Item Type:Article
Date:2012
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
22033803PubMed ID
10.1007/s00210-011-0704-0DOI
Classification:
NotationType
Antidepressive Agents/metabolismMESH
Antipsychotic Agents/metabolismMESH
Binding, CompetitiveMESH
Histamine Agonists/metabolismMESH
Histamine Antagonists/metabolismMESH
HumansMESH
Models, MolecularMESH
Protein BindingMESH
Radioligand AssayMESH
Receptors, Histamine/metabolismMESH
Recombinant Proteins/metabolismMESH
Subjects:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Stefan Dove
Deposited On:15 Nov 2012 09:29
Last Modified:15 Nov 2012 14:44
Item ID:26718
Owner Only: item control page
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