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Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors

Xie, Sheng-Xue and Schalkhausser, Fabian and Ye, Qi-Zhuang and Seifert, Roland and Buschauer, Armin (2007) Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors. Archiv der Pharmazie 340 (1), pp. 9-16.

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Abstract

Imidazolylpropylguanidines derived from impromidine and arpromidine are more potent and efficacious agonists at the guinea pig histamine H₂ receptor (gpH₂R) than at the human H₂R (hH₂R) in the GTPase assay. Additionally, such guanidines are histamine H₁ receptor (H₁R) antagonists with preference for the human relative to the guinea pig receptor. The purpose of this study was to examine ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/ardp.200600140DOI
Keywords:Arpromidine; Guanidines; Histamine H₁ receptor; Histamine H₂ receptor; Impromidine
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:No, this version has not been refereed yet (as with preprints)
Created at the University of Regensburg:Unknown
Owner: Prof. Armin Buschauer
Deposited On:28 Jan 2008 15:10
Last Modified:13 Mar 2014 10:20
Item ID:2672
Owner Only: item control page

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