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The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration

Tsang, K. W. and Roberts, P. and Read, R. C. and Kees, Frieder and Wilson, R. and Cole, P. J. (1994) The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. The Journal of antimicrobial chemotherapy 33 (2), pp. 289-297.

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Abstract

Clarithromycin and its metabolite, 14-hydroxy-clarithromycin are active against a wide range of respiratory pathogens. Antibiotics generally penetrate poorly into respiratory secretions which may therefore continue to harbour bacteria following bronchial infection. We have studied sputum and serum concentrations of clarithromycin and 14-hydroxy-clarithromycin in eight patients with idiopathic ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8182010PubMed ID
Classification:
NotationType
Administration, OralMESH
AdultMESH
AgedMESH
Bronchiectasis/metabolismMESH
Clarithromycin/pharmacokineticsMESH
Drug Administration ScheduleMESH
FemaleMESH
HumansMESH
MaleMESH
Middle AgedMESH
Sputum/metabolismMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:30 Nov 2012 10:47
Last Modified:13 Mar 2014 19:29
Item ID:26823
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