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Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections

Naber, K. G. and Dette, G. A. and Kees, Frieder K. and Knothe, H. and Grobecker, H. (1986) Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. The Journal of antimicrobial chemotherapy 17 (4), pp. 517-527.

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Abstract

The minimal inhibitory concentrations (MICs) of aztreonam and cefotaxime were determined against 400 isolates from urological in-patients with complicated and/or hospital acquired urinary tract infections (UTI). Against the Gram-negative rods the activities of both antibiotics were comparable except for higher activity of aztreonam against Pseudomonas aeruginosa. The pharmacokinetic study in nine ...

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Item Type:Article
Date:1986
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
3710959PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Aztreonam/therapeutic useMESH
Cefotaxime/therapeutic useMESH
Cross Infection/microbiologyMESH
FemaleMESH
Gram-Negative Bacteria/drug effectsMESH
Gram-Positive Bacteria/drug effectsMESH
HumansMESH
Inulin/metabolismMESH
Iothalamic Acid/metabolismMESH
KineticsMESH
MaleMESH
Microbial Sensitivity TestsMESH
Middle AgedMESH
Random AllocationMESH
Urinary Tract Infections/microbiologyMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:30 Nov 2012 10:25
Last Modified:13 Mar 2014 19:29
Item ID:26850
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