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Amiloride enhances the secretion but not the synthesis of renin in renal juxtaglomerular cells

Kurtz, Armin and Della Bruna, R. and Scholz, Holger and Baier, Wolfgang (1991) Amiloride enhances the secretion but not the synthesis of renin in renal juxtaglomerular cells. Pflügers Archiv : European journal of physiology 419 (1), pp. 32-37.

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Abstract

In this study we have examined a potential role of the sodium/proton exchange system in the regulation of renin secretion. We found that the inhibitors of the Na+/H+ antiport, amiloride (1 mM) and ethylisopropylamiloride (EIPA, 50 microM), led to a 125% increase of renin secretion from cultured mouse juxtaglomerular cells. The stimulatory effect of EIPA on renin secretion was dependent on the ...

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Item Type:Article
Date:1991
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
1658729PubMed ID
Classification:
NotationType
Amiloride/pharmacologyMESH
AnimalsMESH
Carrier Proteins/antagonists & inhibitorsMESH
Cells, CulturedMESH
Juxtaglomerular Apparatus/metabolismMESH
Renin/secretionMESH
Saralasin/pharmacologyMESH
Sodium-Hydrogen AntiporterMESH
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:06 Dec 2012 13:49
Last Modified:13 Mar 2014 19:33
Item ID:26960
Owner Only: item control page

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