Kurtz, Armin and Della Bruna, R. and Scholz, Holger and Baier, Wolfgang
Amiloride enhances the secretion but not the synthesis of renin in renal juxtaglomerular cells.
Pflügers Archiv : European journal of physiology 419 (1), pp. 32-37.
In this study we have examined a potential role of the sodium/proton exchange system in the regulation of renin secretion. We found that the inhibitors of the Na+/H+ antiport, amiloride (1 mM) and ethylisopropylamiloride (EIPA, 50 microM), led to a 125% increase of renin secretion from cultured mouse juxtaglomerular cells. The stimulatory effect of EIPA on renin secretion was dependent on the ...
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