Combinatorial Liquid-Phase Synthesis of [1,4]oxazepine-7-ones via the Baylis-Hillman Reaction

Abstract

A new method for the synthesis of [1,4]oxazepin-7-ones from readily available aldehydes and -amino alcohols was developed using the Baylis-Hillman reaction as the key step. To determine the scope and limitations of the method, a mixture library was synthesized from six aldehydes and six -amino alcohols on the soluble polymer support poly(ethylene glycol) 5000 monomethyl ether (MeOPEG) via split synthesis and analyzed by GC-EIMS. Those oxazepines that were formed predominantly were resynthesized in a parallel synthesis and fully characterized. Thus, we have shown that split synthesis on MeOPEG can be an efficient method to rapidly screen the substrate spectrum of a newly developed reaction sequence.