Räcker, Reinhard and Döring, Klaus and Reiser, Oliver (2000) Combinatorial Liquid-Phase Synthesis of [1,4]oxazepine-7-ones via the Baylis-Hillman Reaction. Journal of Organic Chemistry 65 (21), pp. 6932-6939.
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Other URL: http://dx.doi.org/10.102/jo0004916
A new method for the synthesis of [1,4]oxazepin-7-ones from readily available aldehydes and -amino alcohols was developed using the Baylis-Hillman reaction as the key step. To determine the scope and limitations of the method, a mixture library was synthesized from six aldehydes and six -amino alcohols on the soluble polymer support poly(ethylene glycol) 5000 monomethyl ether (MeOPEG) via split synthesis and analyzed by GC-EIMS. Those oxazepines that were formed predominantly were resynthesized in a parallel synthesis and fully characterized. Thus, we have shown that split synthesis on MeOPEG can be an efficient method to rapidly screen the substrate spectrum of a newly developed reaction sequence.
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Helge Knüttel (ADMIN)|
|Deposited On:||01 Sep 2006|
|Last Modified:||05 Aug 2009 15:22|
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