Zorn, Chiara and Gnad, Frieder and Salmen, Sunnhild and Herpin, Timothy and Reiser, Oliver (2001) Deprotection of N-alloc amines by Pd(0) /DABCO: an efficient method for in situ peptide coupling of labile amino acids. Tetrahedron Letters 42 (40), pp. 7049-7053.
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A highly efficient one-pot deprotection/peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (10–20 min) and allowing the coupling of amino acids that are unstable in unprotected forms.
|Date:||1 October 2001|
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Owner:||Helge Knüttel (ADMIN)|
|Deposited On:||01 Sep 2006|
|Last Modified:||05 Aug 2009 13:22|