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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-334586
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.33458
Zusammenfassung
TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to hyperalgesia and allodynia. We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat). Increasing or decreasing Cdk5 ...
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