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Functional Expression of the Interleukin-11 Receptor α-Chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells

Kießling, Stephan and Müller-Newen, Gerhard and Leeb, Sandra N. and Hausmann, Martin and Rath, Heiko C. and Strater, Jörn and Spottl, Tanja and Schlottmann, Klaus and Grossmann, Johannes and Montero-Julian, F. A. and Schölmerich, Jürgen and Andus, Tilo and Buschauer, Armin and Heinrich, Peter C. and Rogler, Gerhard (2004) Functional Expression of the Interleukin-11 Receptor α-Chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells. The Journal of Biological Chemistry 279 (11), pp. 10304-10315.

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Other URL: http://www.jbc.org/cgi/content/full/279/11/10304


Abstract

A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). Despite the fact that the clinical usefulness of the anti-inflammatory effects of this cytokine is presently investigated in patients with IBD, there are no data available regarding the target cells of IL-11 action and the mechanisms of tissue ...

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Item Type:Article
Date:12 March 2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
14701802PubMed ID
10.1074/jbc.M312757200DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 10:08
Last Modified:05 Aug 2009 13:42
Item ID:3371
Owner Only: item control page
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