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Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists.

Preuss, Hendrik and Ghorai, Prasanta and Kraus, Anja and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2007) Point Mutations in the Second Extracellular Loop of the Histamine H2 Receptor do not affect the Species-Selective Activity of Guanidine-Type Agonists. Naunyn Schmiedebergs Arch. Pharmacol. 376 (4), pp. 253-264.

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Other URL: http://www.springerlink.com/content/f04717qq54780325/


Abstract

Residues in the second extracellular loop (e2) play a role in ligand binding in certain aminergic G protein coupled receptors (GPCRs). N-[3-(1H-Imidazol-4-yl)propyl)]guanidines and N G-acylated derivatives are more efficacious and potent agonists at fusion proteins of the guinea pig histamine H2 receptor and the short splice variant of Gsα, GsαS (gpH2R-GsαS) than at the human isoform ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
17999052PubMed ID
10.1007/s00210-007-0204-4DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 07:25
Last Modified:13 Mar 2014 10:25
Item ID:3374
Owner Only: item control page

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