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Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y1 Receptor Antagonist.

Schneider, Erich and Keller, Max and Brennauer, Albert and Hoefelschweiger, Bianca K. and Gross, Dietmar and Wolfbeis, Otto S. and Bernhardt, Günther and Buschauer, Armin (2007) Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y1 Receptor Antagonist. ChemBioChem 8 (16), pp. 1981-1988.

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Other URL: http://www3.interscience.wiley.com/cgi-bin/abstract/116319389/ABSTRACT?CRETRY=1&SRETRY=0


Abstract

Cyanine-5-labelled neuropeptide Y (NPY) was demonstrated to be an ideal universal fluorescent ligand for the combined investigation of NPY Y1, Y2 and Y5 receptors. With respect to improved stability, detection of receptor subtypes in cells and tissues, and prevention of receptor internalization, small nonpeptidic fluorescent antagonists should be superior. Here we present a set of four ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Otto S. Wolfbeis)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/cbic.200700302DOI
17876753PubMed ID
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 07:30
Last Modified:13 Mar 2014 10:25
Item ID:3375
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