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Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions

Brennauer, Albert and Keller, Max and Freund, Matthias and Bernhardt, Günther and Buschauer, Armin (2007) Decomposition of 1-(w-aminoalkanoyl)guanidines under alkaline conditions. Tetrahedron Letters 48 (39), pp. 6996-6999.

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Other URL: http://dx.doi.org/10.1016/j.tetlet.2007.07.147


Abstract

The decomposition of some NG-(ω-aminoalkanoyl)argininamides, which are key intermediates for the preparation of radiolabeled and fluorescent neuropeptide Y receptor ligands, prompted us to synthesize a small series of simple 1-(ω-aminoalkanoyl)guanidines, and to investigate these model compounds for stability in alkaline buffers. The degradation of acylguanidines was monitored by time resolved UV ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
doi:10.1016/j.tetlet.2007.07.147DOI
Keywords:Acylguanidines; Lactam formation; Degradation rate; UV spectroscopy
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 07:57
Last Modified:05 Aug 2009 13:42
Item ID:3376
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