Startseite UB

Tariquidar analogues: synthesis by Cu(I)-catalysed N/O–aryl coupling and inhibitory activity against the ABCB1 transporter.

Egger, Michael and Li, Xuqin and Müller, Christine and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2007) Tariquidar analogues: synthesis by Cu(I)-catalysed N/O–aryl coupling and inhibitory activity against the ABCB1 transporter. European Journal of Organic Chemistry 2007 (16), pp. 2643-2649.

Full text not available from this repository.

at publisher (via DOI)

Other URL: http://www3.interscience.wiley.com/cgi-bin/abstract/114215593/ABSTRACT


Abstract

Less lipophilic and better water soluble tariquidar analogues were synthesised from one central anthranilic acid derived building block by CuI-catalysed N/O-arylation reactions. The compounds were tested for their inhibitory activity against the ABCB1 transporter in a flow cytometric calcein-AM efflux assay. A correlation between their calculated log P values and their activities was observed, ...

plus


Export bibliographical data

Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/ejoc.200700142DOI
Keywords:Cross-coupling; Medicinal chemistry; Lipophilicity
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:21 Feb 2008 08:09
Last Modified:08 Nov 2010 15:12
Item ID:3379
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact