Müller, Christine and Gross, Dietmar and Sarli, Vasiliki and Gartner, Michael and Giannis, Athanassios and Bernhardt, Günther and Buschauer, Armin (2007) Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells. Cancer Chemotherapy and Pharmacology 59 (2), pp. 157-164.
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The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Therefore, we studied the effects of the new monastrol analogues enastron, dimethylenastron and vasastrol VS-83 on the proliferation of human glioblastoma cells in the kinetic crystal violet assay. ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Keywords:||Kinesin inhibitors - Monastrol analogues - Human glioblastoma cells - Chemosensitivity - Confocal microscopy|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||21 Feb 2008 08:14|
|Last Modified:||05 Aug 2009 13:42|