Startseite UB

Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.

Xie, Sheng-Xue and Petrache, Georgiana and Schneider, Erich and Ye, Qi-Zhuang and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorganic & Medicinal Chemistry Letters 16 (15), pp. 3886-3890.

Full text not available from this repository.

at publisher (via DOI)

at PubMed

Other URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4K2SK48-6&_user=616165&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000032338&_version=1&_urlVersion=0&_userid=616165&md5=92ff1302fb50e5982f16de51bf0c9dd3


Abstract

In an effort to develop a non-radioactive alternative to the [3H]tiotidine and [125I]iodoaminopotentidine binding assays for the histamine H2-receptor (H2R), primary amines related to aminopotentidine were prepared and coupled with the succinimidyl esters of the bulky fluorescent dyes S0536 and BODIPY 650/665-X. The primary amines exhibited different degrees of antagonistic potency at the human ...

plus


Export bibliographical data



Item Type:Article
Date:2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1016/j.bmcl.2006.05.039DOI
16730977PubMed ID
Keywords:Fluorescent probes; Cyanine; BODIPY; Histamine H2-receptor agonist; GTPase assay
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 08:30
Last Modified:05 Aug 2009 13:42
Item ID:3384
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact