Startseite UB

Design of new benzoxazole-2-thione derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.

Rigden, Daniel J. and Botzki, Alexander and Nukui, Masatoshi and Mewbourne, R. Brandon and Lamani, Ejvis and Braun, Stephan and von Angerer, Erwin and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin and Jedrzejas, Mark J. (2006) Design of new benzoxazole-2-thione derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole. Glycobiology 16 (8), pp. 757-765.

Full text not available from this repository.

at PubMed

at publisher (via DOI)

Other URL: http://glycob.oxfordjournals.org/cgi/content/full/16/8/757


Abstract

The bacterial hyaluronan lyases (Hyals) that degrade hyaluronan, an important component of the extracellular matrix, are involved in microbial spread. Inhibitors of these enzymes are essential in investigation of the role of hyaluronan and Hyal in bacterial infections and constitute a new class of antibiotics against Hyal-producing bacteria. Recently, we identified ...

plus


Export bibliographical data

Item Type:Article
Date:2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
16638841PubMed ID
10.1093/glycob/cwj116DOI
Keywords:antimicrobials / hyaluronidase / molecular mechanism / pneumococci / spreading factor
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 08:40
Last Modified:05 Aug 2009 13:42
Item ID:3387
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact