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Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,

Botzki, Alexander and Salmen, Sunnhild and Bernhardt, Günther and Buschauer, Armin and Dove, Stefan (2005) Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,. QSAR & Combinatorial Science 24 (4), pp. 458-469.

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Other URL: http://www3.interscience.wiley.com/cgi-bin/abstract/109925329/ABSTRACT


Abstract

Hyaluronidases depolymerize hyaluronic acid, an important component of the extracellular matrix. Bacterial hyaluronan lyases (EC 4.2.2.1) contribute to the spreading of microorganisms in tissues. Potent and selective inhibitors are not known up to now, but would be interesting pharmacological tools and potential drugs for the treatment of bacterial infections. Starting from two crystal structures ...

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Item Type:Article
Date:2005
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/qsar.200430930DOI
Keywords:Hyaluronidase inhibitors • LUDI • Property distribution • Structure-based design
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 08:50
Last Modified:05 Aug 2009 13:42
Item ID:3389
Owner Only: item control page
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