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Construction and validation of a microprocessor controlled extracorporal circuit in rats for the optimization of isolated limb perfusion.

Gürtler, Ulrich ; Fuchs, Peter ; Stangelmayer, Achim ; Bernhardt, Günther ; Buschauer, Armin ; Spruss, Thilo



Zusammenfassung

Although a few experimental approaches to isolated limb perfusion (ILP) are described in the literature, none of these animal models mimics the clinical perfusion techniques adequately to improve the technique of ILP on the basis of valid preclinical data. Therefore, we developed an ILP setup in rats allowing online monitoring of essential perfusion parameters such as temperature (in perfusate, ...

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