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Structure-Activity Relationships of Histamine H_2 Receptor Ligands,

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-Activity Relationships of Histamine H_2 Receptor Ligands,. Mini-Rev. Med. Chem. 4 (9), pp. 941-954.

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Other URL: http://www.ingentaconnect.com/content/ben/mrmc/2004/00000004/00000009/art00004?token=004f1d607b82cf8aa68233f7b2f27375f2a72752d705e437a63736a425547414c76662525532a2b


Abstract

Recent research on histamine H2 receptor agonists was focused on quantitative structure-activity relationships and receptor models explaining the activity of imidazolylpropylguanidines. Their selectivity for guinea pig vs. human isoforms was investigated using H2 receptor-Gsalpha fusion proteins and attributed to amino acid differences in transmembrane domains 1 and 7. New antagonists result from ...

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Item Type:Article
Date:2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
15544555PubMed ID
UNSPECIFIEDDOI
Keywords:h2 receptor agonists; h2 receptor antagonists; impromidine analogues; arpromidine; molecular modelling; structure-activity relationships; qsar; site-directed mutagenesis
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 09:42
Last Modified:05 Aug 2009 13:42
Item ID:3391
Owner Only: item control page
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