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Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues from Patients

Teufel, Andreas ; Itzel, Timo ; Erhart, W. ; Brosch, M. ; Wang, X. Y. ; Kim, Y. O. ; von Schoenfels, Witigo ; Herrmann, A. ; Bruckner, S. ; Stickel, F. ; Dufour, J. F. ; Chavakis, T. ; Hellerbrand, Claus ; Spang, Rainer ; Maass, Thorsten ; Becker, T. ; Schreiber, S. ; Schafmayer, C. ; Schuppan, D. ; Hampe, J.



Zusammenfassung

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Mouse models of NAFLD have been used in studies of pathogenesis and treatment, and have certain features of the human disease. We performed a systematic transcriptome-wide analysis of liver tissues from patients at different stages of NAFLD progression (ranging from ...

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