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Structure-Activity Relationships of Nonpeptide Neuropeptide Y Receptor Antagonists

Brennauer, Albert and Dove, Stefan and Buschauer, Armin (2004) 18. Structure-Activity Relationships of Nonpeptide Neuropeptide Y Receptor Antagonists. In: Michel, M. C., (ed.) Neuropeptide Y and Related Peptides. Handbook of Experimental Pharmacology, 162 (18). Springer, Heidelberg, pp. 505-546. ISBN 978-3-540-40581-8.

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Other URL: http://www.springer.com/biomed/pharmaceutical+science/book/978-3-540-40581-8


Abstract

Reports in 1990 on some weakly to moderately active nonpeptides which were not originally designed for neuropeptide Y (NPY) receptors, followed by the discovery of the first highly potent and selective Y1 receptor antagonists-the (R)-argininamide BIBP 3226 and the benzamidine deriv. SR 120819A-as well as raising hope for novel drug treatment of hypertension, obesity and metabolic diseases ...

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Export bibliographical data

Item Type:Book Section
Date:2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 09:51
Last Modified:05 Aug 2009 13:42
Item ID:3393
Owner Only: item control page
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