Seifert, Roland and Wenzel-Seifert, Katharina and Bürckstümmer, Tilmann and Pertz, Heinz H. and Schunack, Walter and Dove, Stefan and Buschauer, Armin and Elz, Sigurd (2003) Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,. Journal of Pharmacology and Experimental Therapeutics 305, pp. 1104-1115.
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Species isoforms of histamine H2-, H3-, and H4-receptors differ in their pharmacological properties. The study aim was to dissect differences between the human H1R (hH1R) and guinea pig H1R (ghH1R). We coexpressed hH1R and gpH1R with regulators of G-protein signaling in Sf9 insect cells and analyzed the GTPase activity of Gq-proteins. Small H1R agonists showed similar effects at hH1R and gpH1R, ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||21 Feb 2008 10:00|
|Last Modified:||12 Aug 2009 03:04|