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Synthesis and pharmacological activity of fluorescent histamine H1 receptor antagonists related to mepyramine,

Li, Liantao and Kracht, Julia and Peng, Shiqi and Bernhardt, Günther and Buschauer, Armin (2003) Synthesis and pharmacological activity of fluorescent histamine H1 receptor antagonists related to mepyramine,. Bioorganic & Medicinal Chemistry Letters 13 (7), pp. 1245-1248.

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Other URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-481777G-2&_user=616165&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000032338&_version=1&_urlVersion=0&_userid=616165&md5=1256802a8d194b3a5281bc576a533f93


Abstract

Fluorescently labeled histamine H1 receptor antagonists were synthesized starting from N-demethylmepyramine by introduction of ω-aminoalkyl chains (2–8 methylene groups in length) followed by derivatization of the terminal NH2 group with various fluorophores (fluorescein, naphthofluorescein, rhodamine, tetramethylrhodamine, BODIPY, dansyl, and nitrobenzoxadiazole (NBD)). On the isolated guinea ...

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Item Type:Article
Date:2003
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1016/S0960-894X(03)00113-6DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 10:20
Last Modified:05 Aug 2009 13:42
Item ID:3397
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